Heart and blood vessel disease lead to heart attacks, strokes, and kidney disease, all complications of Type 2 diabetes. Out-of-control blood sugar is a major factor in vascular complications. Now, research is beginning to solve the mystery of how high blood sugars can be associated with damage to the blood vessels.
Deoxyribonucleic acid, DNA for short, is responsible for making us the biological selves we are. It is found in almost all human cells, and gives your cells machinery instructions for making proteins. The type of protein produced controls how your cells function. DNA provides:
the beta cells of your pancreas with instructions for making insulin,
intestinal cells with instructions on absorbing nutrients, and
your brain cells with instructions on processing information.
As your body repairs and renews itself, old cells divide to make new cells to take their place. During cell division DNA molecules can become broken. Some research has shown a high degree of DNA breakage in people diagnosed with Type 2 diabetes.
As early as 1986, the Journal of Clinical Investigation reported high blood sugar levels sped the rate of death and interfered with cell replication in human blood vessel cells in glass containers.
From this it was suggested the blood vessel damage often seen in diabetics could be due to high sugar levels in the blood breaking down DNA molecules in the blood vessel cells.
More recently, investigators at the Federal University of Santa Maria in Brazil designed and carried out a study to discover whether the inflammation and blood vessel damage often associated with Type 2 diabetes could be associated with DNA breakage.
The study, published in the journal Mutation Research in January 2012, included 30 non-diabetics and 32 Type 2 diabetics. The volunteers with Type 2 diabetes:
had more DNA breakage than the healthy volunteers.
they also showed higher levels of interleukin-6, a molecule associated with inflammation,
more protein in their urine, a sign of kidney disease, and
a lower proportion of nitrates to nitrites. The proportion of nitrates to nitrites indicates inflammation, and the lower the ratio is, the higher the amount of inflammation exists.
Among the Type 2 diabetics, high levels of DNA breakage were associated with higher levels of blood sugar.
Healthy DNA is necessary for cell health, and it appears high blood sugar levels, exposing blood vessel cells to a high sugar environment, is likely to damage their DNA. Whether diabetics acquire heart and blood vessel disease could be a function of their ability or inability to repair DNA.
So the best idea is to keep your blood sugar levels within normal limits and this is more than likely a good way to prevent the need for too many DNA repairs.
Deoxyribonucleic acid, DNA for short, is responsible for making us the biological selves we are. It is found in almost all human cells, and gives your cells machinery instructions for making proteins. The type of protein produced controls how your cells function. DNA provides:
the beta cells of your pancreas with instructions for making insulin,
intestinal cells with instructions on absorbing nutrients, and
your brain cells with instructions on processing information.
As your body repairs and renews itself, old cells divide to make new cells to take their place. During cell division DNA molecules can become broken. Some research has shown a high degree of DNA breakage in people diagnosed with Type 2 diabetes.
As early as 1986, the Journal of Clinical Investigation reported high blood sugar levels sped the rate of death and interfered with cell replication in human blood vessel cells in glass containers.
From this it was suggested the blood vessel damage often seen in diabetics could be due to high sugar levels in the blood breaking down DNA molecules in the blood vessel cells.
More recently, investigators at the Federal University of Santa Maria in Brazil designed and carried out a study to discover whether the inflammation and blood vessel damage often associated with Type 2 diabetes could be associated with DNA breakage.
The study, published in the journal Mutation Research in January 2012, included 30 non-diabetics and 32 Type 2 diabetics. The volunteers with Type 2 diabetes:
had more DNA breakage than the healthy volunteers.
they also showed higher levels of interleukin-6, a molecule associated with inflammation,
more protein in their urine, a sign of kidney disease, and
a lower proportion of nitrates to nitrites. The proportion of nitrates to nitrites indicates inflammation, and the lower the ratio is, the higher the amount of inflammation exists.
Among the Type 2 diabetics, high levels of DNA breakage were associated with higher levels of blood sugar.
Healthy DNA is necessary for cell health, and it appears high blood sugar levels, exposing blood vessel cells to a high sugar environment, is likely to damage their DNA. Whether diabetics acquire heart and blood vessel disease could be a function of their ability or inability to repair DNA.
So the best idea is to keep your blood sugar levels within normal limits and this is more than likely a good way to prevent the need for too many DNA repairs.